24. Januar 2025

Study on the biological impact of the absorption of drugs on nanoplastics Study on the biological impact of the absorption of drugs on nanoplastics

In a recent publication in Scientific Reports, an international research team with involvement of Prof. Barbara Kirchner  has investigated how nanoplastic particles in the body can influence the effectiveness of antibiotics.

Adsorption of the antibiotic tetracycline on a nylon 6,6 (N66) nanoplastics particle
Adsorption of the antibiotic tetracycline on a nylon 6,6 (N66) nanoplastics particle © L. Dick
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The research teams of Prof. Barbara Kirchner, Prof.  Oldamur Hollóczki (Universität Debrecen, Hungary) and Prof. Lukas Kenner (Medical University Vienna, Austria) studied  how the broad spectrum antibiotic tetracycline  behaves in the presence of some widely used plastics like  Nylon 66 (N66),  Polystyrene (PS), Polypropylene (PP)  and Polyethylene (PE) using theoretical and experimental approaches.

The results show that nanoplastics can both adsorb tetracycline on their surface and completely absorb the antibiotic, with the adsorption affinity following the order Nylon 66 (N66) > Polystyrene (PS) > Polypropylene (PP) > Polyethylene (PE). The effectiveness of tetracycline decreases in the presence of plastics. Classical molecular dynamics simulations confirm the stability and mobility of the tetracycline-nanoplastic complexes. The reversible adsorption suggests that nanoplastics have the potential to transport tetracycline across different environments, raising concerns about unwanted drug exposure and the development of antibiotic-resistant bacteria. These results highlight the potential health and environmental risks associated with nanoplastics and the need for further research to better understand their effects.

The study has attracted a lot of attention and has been quoted in news articles and blogs. The article is in the 99th percentile of all tracked articles of a similar age in all journals:

Link to the Article Metric on nature.com1

This project was funded by the Deutsche Forschungsgemeinschaft (DFG,German Research Foundation) as part of the CRC 1639 NuMeriQS - project no. 511713970. P.R.B. would like to thank São Paulo Research Foundation (FAPESP) for financial support and the National Laboratory for Scientific Computing, Brazil for providing computational HPC resources.

L. Dick, P. R. Batista, P. Zaby, G. Manhart, V. Kopatz, L. Kogler, V. Pichler, F. Grebien, V. Bakos, B G. Plósz, N. Zlatkov Kolev, L. Kenner, B. Kirchner, O. Hollóczki, The adsorption of drugs on nanoplastics has severe biological impact, Sci. Rep. (2024), 14, 25853.   DOI: 10.1038/s41598-024-75785-42

Prof. Dr. Barbara Kirchner
Mulliken Center for Theoretical Chemistry
Clausius Institut für Physikalische und Theoretische Chemie
Beringstr. 4
53115 Bonn
kirchner@thch.uni-bonn.de

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