Publications

(260) Z. Yin, H. Xu, J. S. Dickschat, A clickable coenzyme A derived probe for investigating phosphopantetheinyl transferase activity in natural product biosynthesis, Org. Biomol. Chem. 2024, 22, accepted.
DOI: 10.1039/D4OB01485E

(259) F.-L. Lin, K. A. Taizoumbe, Y.-X. Wang, J.-H. Huang, G.-Q. Wang, G.-D. Chen, J.-M. Lv, D. Hu, H. Gao, J. S. Dickschat, Mechanistic characterisation of a fungal fusicoccane-type diterpene synthase involved in the biosynthesis of talaro-7,13-diene, Org. Biomol. Chem. 2024, 22, 7971-7975.
DOI: 10.1039/D4OB01348D

(258a) G. B. Tabekoueng, H. Li, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, Skelettumlagerungen in der enzymkatalysierten Biosynthese korallenartiger Diterpene aus Chitinophaga pinensis, Angew. Chem. 2024, 136, e202413860.
DOI: 10.1002/ange.202413860
(258b) G. B. Tabekoueng, H. Li, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, Skeletal Rearrangements in the Enzyme-Catalysed Biosynthesis of Coral-type Diterpenes from Chitinophaga pinensis, Angew. Chem. Int. Ed. 2024, 63, e202413860.
DOI: 10.1002/anie.202413860

(257a) H. Xu, H. Li, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, Biosynthese der nichtkanonischen C17-Sesquiterpenoide Chlororaphen A und B aus Pseudomonas chlororaphis, Angew. Chem. 2024, 136, e202412040.
DOI: 10.1002/ange.202412040
(257b) H. Xu, H. Li, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, Biosynthesis of the Non-canonical C17 Sesquiterpenoids Chlororaphen A and B from Pseudomonas chlororaphis, Angew. Chem. Int. Ed. 2024, 63, e202412040.
DOI: 10.1002/anie.202412040

(256) M. Kostka, D. Krug, J. Herrmann, J. S. Dickschat, J. Meyer, R. Müller, S. Schulz, Identification by Synthesis: Imidacins, Urocanate Derived Alkaloids from the Myxobacterium Stigmatella aurantiaca, Org. Lett. 2024, 26, 6359-6363.
DOI: 10.1021/acs.orglett.4c02036

(255) H. Struwe, H. Li, F. Schrödter, L. Höft, J. Fohrer, J. S. Dickschat, A. Kirschning, Telescoping a prenyltransferase and a diterpene synthase to transform unnatural FPP derivatives to diterpenoids, Org. Lett. 2024, 26, 5888-5892.
DOI: 10.1021/acs.orglett.4c01670

(254a) J.-Y. Liu, F.-L. Lin, K. A. Taizoumbe, J.-M. Lv, Y.-H. Wang, G.-Q. Wang, G.-D. Chen, X.-S. Yao, D. Hu, H. Gao, J. S. Dickschat, A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation-Reprotonation Process, Angew. Chem. 2024, 136, e202407895.
DOI: 10.1002/ange.202407895
(254b) J.-Y. Liu, F.-L. Lin, K. A. Taizoumbe, J.-M. Lv, Y.-H. Wang, G.-Q. Wang, G.-D. Chen, X.-S. Yao, D. Hu, H. Gao, J. S. Dickschat, A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation-Reprotonation Process, Angew. Chem. Int. Ed. 2024, 63, e202407895.
DOI: 10.1002/anie.202407895

(253) K. A. Taizoumbe, A. K. Chhalodia, B. Goldfuss, J. S. Dickschat, Experiment Meets Theory: Cope Rearrangements and Thermal E/Z Isomerisations of Terpenoid Hydrocarbons, Eur. J. Org. Chem. 2024, 27, e202400583.
DOI: 10.1002/ejoc.202400583

(252a) H. Xu, B. Goldfuss, J. S. Dickschat, Gemeinsame Biosynthese nichtkanonischer C16-Terpene durch einen Fragmentierungs-Rekombinations-Mechanismus, Angew. Chem. 2024, 136, e202408809.
DOI: 10.1002/ange.202408809
(252b) H. Xu, B. Goldfuss, J. S. Dickschat, Common Biosynthesis of Non-canonical C16 Terpenes through a Fragmentation-Recombination Mechanism, Angew. Chem. Int. Ed. 2024, 63, e202408809.
DOI: 10.1002/anie.202408809

(251) Z. Yin, M. Maczka, G. Schnakenburg, S. Schulz, J. S. Dickschat, Enantioselective synthesis of all stereoisomers of geosmin and of biosynthetically related natural products, Org. Biomol. Chem. 2024, 22, 5748-5758.
DOI: 10.1039/D4OB00934G

(250) H. Li, B. Goldfuss, J. S. Dickschat, Mechanistic Characterisation of the Diterpene Synthase for Clitopilene and Identification of Isopentalenene Synthase from the fungus Clitopilus passeckerianus, ChemComm 2024, 60, 7041-7044.
DOI: 10.1039/D4CC02286F

(249a) M. Xu, H. Xu, Z. Lei, B. Xing, J. S. Dickschat, D. Yang, M. Ma, Structural Insights into the Terpene Cyclization Domains of Two Fungal Sesterterpene Synthases and Enzymatic Engineering for Sesterterpene Diversification, Angew. Chem. 2024, 136, e202405140.
DOI: 10.1002/ange.202405140
(249b) M. Xu, H. Xu, Z. Lei, B. Xing, J. S. Dickschat, D. Yang, M. Ma, Structural Insights into the Terpene Cyclization Domains of Two Fungal Sesterterpene Synthases and Enzymatic Engineering for Sesterterpene Diversification, Angew. Chem. Int. Ed. 2024, 63, e202405140.
DOI: 10.1002/anie.202405140

(248) Z. Yin, J. S. Dickschat, Substrate Specificity of a Ketosynthase Domain Involved in Bacillaene Biosynthesis, Beilstein J. Org. Chem. 2024, 20, 734-740.
DOI: 10.3762/bjoc.20.67

(247) A. K. Chhalodia, J. S. Dickschat, On the Substrate Scope of Dimethylsulfonium Propionate Lyases toward Dimethylsulfoxonium Propionate Derivatives, Eur. J. Org. Chem. 2024, 27, e202400098.
DOI: 10.1002/ejoc.202400098

(246) H. Xu, T. G. Köllner, F. Chen, J. S. Dickschat, Functional and Mechanistic Characterization of the 4,5-diepi-Isoishwarane Synthase from the Liverwort Radula lindenbergiana, ChemBioChem 2024, 25, e202400104.
DOI: 10.1002/cbic.202400104

(245a) B. Gu, B. Goldfuss, J. S. Dickschat, Zwei Sesterterpen-Syntasen aus Lentzea atacamensis demonstrieren die Rolle der Konformationsvariabilität in der Terpenbiosynthese, Angew. Chem. 2024, 136, e202401539.
DOI: 10.1002/ange.202401539
(245b) B. Gu, B. Goldfuss, J. S. Dickschat, Two Sesterterpene Synthases from Lentzea atacamensis Demonstrate the Role of Conformational Variability in Terpene Biosynthesis, Angew. Chem. Int. Ed. 2024, 63, e202401539.
DOI: 10.1002/anie.202401539

(244) H. Xu, J. S. Dickschat, Isotopic Labelings for Mechanistic Studies, Method. Enzymol. 2024, 699, 163-186.
DOI: 10.1016/bs.mie.2024.01.011

(243) H. Xu, T. G. Köllner, F. Chen, J. S. Dickschat, Mechanistic Characterisation of a Sesquiterpene Synthase for Asterisca-1,6-diene from the Liverwort Radula lindenbergiana and Implications for Pentalenene Biosynthesis, Org. Biomol. Chem. 2024, 22, 1360-1364.
DOI: 10.1039/D3OB02088F

(242a) K. A. Taizoumbe, B. Goldfuss, J. S. Dickschat, Das Diterpenoide Substratanalogon 19-nor-GGPP deckt ausgeprägte Methylgruppeneffekte bei Diterpencyclisierungen auf, Angew. Chem. 2024, 136, e202318375.
DOI: 10.1002/ange.202318375
(242b) K. A. Taizoumbe, B. Goldfuss, J. S. Dickschat, The Diterpenoid Substrate Analog 19-nor-GGPP Uncovers Pronounced Methyl Group Effects in Diterpene Cyclisations, Angew. Chem. Int. Ed. 2024, 63, e202318375.
DOI: 10.1002/anie.202318375

(241) A. K. Chhalodia, J. S. Dickschat, The Stereochemical Course of DmdC, an Enzyme Involved in the Degradation of Dimethylsulfoniopropionate, ChemBioChem 2024, 25, e202300795.
DOI: 10.1002/cbic.202300795

(240) H. Li, J. S. Dickschat, Enzymatic Synthesis of Diterpenoids from iso-GGPP III: A Geranylgeranyl Diphosphate Analog with Shifted Double Bond, Chem. Eur. J. 2024, 30, e202303560.
DOI: 10.1002/chem.202303560

(239a) Z. Huang, K. A. Taizoumbe, C. Liang, B. Goldfuss, J. Xu, J. S. Dickschat, Spiroluchuen-A-Synthase: Eine Cyclase aus Aspergillus luchuensis, die ein spirotetracyclisches Diterpen bildet, Angew. Chem. 2023, 135, e202315659.
DOI: 10.1002/ange.202315659
(239b) Z. Huang, K. A. Taizoumbe, C. Liang, B. Goldfuss, J. Xu, J. S. Dickschat, Spiroluchuene A Synthase: A Cyclase from Aspergillus luchuensis Forming a Spirotetracyclic Diterpene, Angew. Chem. Int. Ed. 2023, 62, e202315659.
DOI: 10.1002/anie.202315659

(238a) B. Gu, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, Subrutilan – ein Hexacyclisches Sesterterpen aus Streptomyces subrutilus, Angew. Chem. 2023, 135, e202313789.
DOI: 10.1002/ange.202313789
(238b) B. Gu, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, Subrutilane – A Hexacyclic Sesterterpene from Streptomyces subrutilus, Angew. Chem. Int. Ed. 2023, 62, e202313789.
DOI: 10.1002/anie.202313789

(237) J. S. Dickschat, Z. Quan, G. Schnakenburg, A Case of Convergent Evolution: The Bacterial Sesquiterpene Synthase for 1-epi-Cubenol from Nonomuraea coxensis, ChemBioChem 2023, 24, 202300581.
DOI: 10.1002/cbic.202300581

(236) B. Gu, L. Liang, J. S. Dickschat, Functions of enzyme domains in 2-methylisoborneol biosynthesis and enzymatic synthesis of non-natural analogs, Beilstein J. Org. Chem. 2023, 19, 1452-1459.
DOI: 10.3762/bjoc.19.104

(235) H. Xu, J. S. Dickschat, Turning a Sesquiterpene Synthase into a Di- and Sesterterpene Synthase, ACS Catal. 2023, 13, 12723–12729.
DOI: 10.1021/acscatal.3c03740

(234) A. K. Chhalodia, H. Xu, G. B. Tabekoueng, B. Gu, K. A. Taizoumbe, L. Lauterbach, J. S. Dickschat, Functional Characterisation of Twelve Terpene Synthases from Actinobacteria, Beilstein J. Org. Chem. 2023, 19, 1386-1398.
DOI: 10.3762/bjoc.19.100

(233) K. A. Taizoumbe, S. T. Steiner, J. S. Dickschat, Mechanistic Characterisation of Collinodiene Synthase, a Diterpene Synthase from Streptomyces collinus, Chem. Eur. J. 2023, 29, e202302469.
DOI: 10.1002/chem.202302469

(232a) B. Gu, J. S. Dickschat, Ruptene – Eine Familie von Terpenanaloga Erlaubt Einblicke in Cyclisierungsmechanismen durch Unterbrechung der Kaskade, Angew. Chem. 2023, 135, e202307006.
DOI: 10.1002/ange.202307006
(232b) B. Gu, J. S. Dickschat, Ruptenes – A Family of Terpene Analogs Give Insight into Cyclisation Mechanisms by Cascade Disruption, Angew. Chem. Int. Ed. 2023, 62, e202307006.
DOI: 10.1002/anie.202307006

(231a) H. Xu, G. Schnakenburg, B. Goldfuss, J. S. Dickschat, Mechanistische Characterisierung der Bakteriellen Sesterviriden-Synthase aus Kitasatospora viridis, Angew. Chem. 2023, 135, e202306429.
DOI: 10.1002/ange.202306429
(231b) H. Xu, G. Schnakenburg, B. Goldfuss, J. S. Dickschat, Mechanistic Characterisation of the Bacterial Sesterviridene Synthase from Kitasatospora viridis, Angew. Chem. Int. Ed. 2023, 62, e202306429.
DOI: 10.1002/anie.202306429

(230) A. Santarcangelo, F. Weber, S. Kehraus, J. S. Dickschat, A. Schieber, Generation and structure elucidation of a red colorant formed by oxidative coupling of chlorogenic acid and tryptophan, Food Chem. 2023, 425, 136473.
DOI: 10.1016/j.foodchem.2023.136473

(229) A. Hou, B. Li, Z. Deng, M. Xu, J. S. Dickschat, Cladosporin, A Highly Potent Antimalaria Drug? ChemBioChem 2023, 24, e202300154.
DOI: 10.1002/cbic.202300154

(228) H. Xu, B. Goldfuss, J. S. Dickschat, Biosynthesis of the Sesquiterpene Kitaviridene through Skeletal Rearrangement with Formation of a Methyl Group Equivalent, Org. Lett. 2023, 25, 3330-3334.
DOI: 10.1021/acs.orglett.3c01211

(227) H. Xu, L. Lauterbach, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, Fragmentation and [4+3] Cycloaddition in Sodorifen Biosynthesis, Nat. Chem. 2023, 15, 1164-1171.
DOI: 10.1038/s41557-023-01223-z

(226) K. Schell, H. Li, L. Lauterbach, K. A. Taizoumbe, J. S. Dickschat, B. Hauer, Alternative Active Site Confinement in Squalene–Hopene Cyclase Enforces Substrate Preorganization for Cyclization, ACS Catal. 2023, 13, 5073-5083.
DOI: 10.1021/acscatal.2c05949

(225) B. Gu, J. S. Dickschat, Functional Characterisation of Highly Conserved and Structurally Prominent Residues of 2-Methylisoborneol Synthase, Chem. Eur. J. 2023, 29, e202300775.
DOI: 10.1002/chem.202300775

(224) T. Lou, A. Li, H. Xu, J. Pan, B. Xing, R. Wu, J. S. Dickschat, D. Yang, M. Ma, Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis, J. Am. Chem. Soc. 2023, 145, 8474-8485.
DOI: 10.1021/jacs.3c00278

(223) P. Garbeva, M. Avalos, D. Ulanova, G. P. van Wezel, J. S. Dickschat, Volatile Sensation: The Chemical Ecology of the Earthy Odorant Geosmin, Environ. Microbiol. 2023, 25, 1565-1574.
DOI: 10.1111/1462-2920.16381

(222) A. K. Chhalodia, J. S. Dickschat, Discovery of Dimethylsulfoxonium Propionate Lyases – A Missing Enzyme Relevant to the Global Sulfur Cycle, Org. Biomol. Chem. 2023, 21, 3083-3089.
DOI: 10.1039/D2OB02288E

(221) N. B. Kreuzenbeck, S. Dhiman, D. Roman, I. Burkhardt, B. H. Conlon, J. Fricke, H. Guo, J. Blume, H. Görls, M. Poulsen, J. S. Dickschat, T. G. Köllner, H.-D. Arndt, C. Beemelmanns, Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi, Comms. Chem. 2023, 6, 79.
DOI: 10.1038/s42004-023-00871-z

(220) H. Xu, J. S. Dickschat, A Detailed View on Geosmin Biosynthesis, ChemBioChem 2023, 24, e202300101.
DOI: 10.1002/cbic.202300101

(219) H. Xu, J. S. Dickschat, Germacrene B – A Central Intermediate in Sesquiterpene Biosynthesis, Beilstein J. Org. Chem. 2023, 19, 186-203.
DOI: 10.3762/bjoc.19.18

(218) A. Hou, J. S. Dickschat, Labelling Studies in Polyketide and Non-ribosomal Peptide Biosynthesis, Nat. Prod. Rep. 2023, 40, 470-499.
DOI: 10.1039/D2NP00071G

(217a) B. Gu, B. Goldfuss, J. S. Dickschat, Mechanistische Charakterisierung und Engineering der Sesterviolen-Synthase aus Streptomyces violens, Angew. Chem. 2023, 135, e202215688.
DOI: 10.1002/ange.202215688
(217b) B. Gu, B. Goldfuss, J. S. Dickschat, Mechanistic Characterisation and Engineering of Sesterviolene Synthase from Streptomyces violens, Angew. Chem. Int. Ed. 2023, 62, e202215688.
DOI: 10.1002/anie.202215688

(216) Z. Yin, J. S. Dickschat, Engineering fungal terpene biosynthesis, Nat. Prod. Rep. 2023, 40, 28-45.
DOI: 10.1039/D2NP00020B

(215) Z. Yin, D. Bär, B. Gust, J. S. Dickschat, The Substrate Scope of Dehydratases in Antibiotic Biosynthesis and their Application in Kinetic Resolutions, Org. Biomol. Chem. 2022, 20, 9103-9107.
DOI: 10.1039/D2OB01879A

(214) C. Zhou, X. Cao, Y. Ge, X. Wu, Z. Xiaodan, Y. Ma, J. S. Dickschat, B. Wu, Talaropeptins A and B, Tripeptides with an N-trans-cinnamoyl Moiety from the Marine-Derived Fungus Talaromyces purpureogenus CX11, J. Nat. Prod. 2022, 85, 2620-2625.
DOI: 10.1021/acs.jnatprod.2c00638

(213) D. Baer, B. Konetschny, A. Kulik, H. Xu, D. Paccagnella, P. Beller, N. Ziemert, J. S. Dickschat, B. Gust, Origin of the 3-Methylglutaryl Moiety in Caprazamycin Biosynthesis, Microb. Cell Fact. 2022, 21, 232.
DOI: 10.1186/s12934-022-01955-6

(212a) H. Li, J. S. Dickschat, Diterpenbiosynthese aus Geranylgeranyldiphosphat-Analoga mit veränderter Reaktivität erweitert die Diversität der Skelette, Angew. Chem. 2022, 134, e202211054.
DOI: 10.1002/ange.202211054
(212b) H. Li, J. S. Dickschat, Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity, Angew. Chem. Int. Ed. 2022, 61, e202211054.
DOI: 10.1002/anie.202211054

(211) H. Xu, A. Wochele, M. Luo, G. Schnakenburg, Y. Sun, H. Brötz-Oesterhelt, J. S. Dickschat, Synthesis of Tryptophan-Dehydrobutyrine Diketopiperazine and Biological Activity of Hangtaimycin and its Co-metabolites, Beilstein J. Org. Chem. 2022, 18, 1159-1165.
DOI: 10.3762/bjoc.18.120

(210) H. Guo, J.-M. Daniel, E. Seibel, I. Burkhardt, B. H. Conlon, H. Görls, D. Giddings Vassao, J. S. Dickschat, M. Poulsen, C. Beemelmanns, Insights into the metabolomic capacity of Podaxis and isolation of podaximycins A-D, ergosterol derivatives carrying nitrosyl cyanide-derived modifications, J. Nat. Prod. 2022, 85, 2159-2167.
DOI: 10.1021/acs.jnatprod.2c00380

(209a) B. Xing, H. Xu, A. Li, T. Lou, M. Xu, K. Wang, Z. Xu, J. S. Dickschat, D. Yang, M. Ma, Kristallstrukturbasierte Mutagenese der Cattleyene-Synthase führt zur Bildung umgelagerter polycyclischer Diterpene, Angew. Chem. 2022, 134, e202209785.
DOI: 10.1002/ange.202209785
(209b) B. Xing, H. Xu, A. Li, T. Lou, M. Xu, K. Wang, Z. Xu, J. S. Dickschat, D. Yang, M. Ma, Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes, Angew. Chem. Int. Ed. 2022, 61, e202209785.
DOI: 10.1002/anie.202209785

(208) B. Gu, A. Hou, J. S. Dickschat, The Stereochemical Course of 2-Methylisoborneol Biosynthesis, Beilstein J. Org. Chem. 2022, 18, 818-824.
DOI: 10.3762/bjoc.18.82

(207) L. Drummond, P. J. Haque, B. Gu, J. S. Jung, H. Schewe, J. S. Dickschat, M. Buchhaupt, High Versatility of IPP and DMAPP Methyltransferases Enables Synthesis of C6, C7 and C8 Terpenoid Building Blocks, ChemBioChem 2022, 23, e202200091.
DOI: 10.1002/cbic.202200091

(206) H. Tao, L. Lauterbach, G. Bian, R. Chen, A. Hou, T. Mori, S. Cheng, B. Hu, L. Lu, X. Mu, M. Li, N. Adachi, M. Kawasaki, T. Moriya, T. Senda, X. Wang, Z. Deng, I. Abe, J. S. Dickschat, T. Liu, Discovery of non-squalene triterpenes, Nature 2022, 606, 414-419.
DOI: 10.1038/s41586-022-04773-3

(205) Z. Yin, E. Liebhart, E. Stegmann, H. Brötz-Oesterhelt, J. S. Dickschat, An Isotopic Probe to Follow the Stereochemical Course of Dehydratase Reactions in Polyketide and Fatty Acid Biosynthesis, Org. Chem. Front. 2022, 9, 2714-2720.
DOI: 10.1039/D2QO00272H

(204) J. Liang, A. T. Merrill, C. J. Laconsay, A. Hou, Q. Pu, J. S. Dickschat, D. J. Tantillo, Q. Wang, R. J. Peters, Deceptive complexity in formation of cleistantha-8,12-diene, Org. Lett. 2022, 24, 2646-2649.
DOI: 10.1021/acs.orglett.2c00680

(203) B. Gu, J. S. Dickschat, A Non-Natural Biosynthesis Pathway toward 2-Methylisoborneol, ChemComm 2022, 58, 4316-4319.
DOI: 10.1039/D2CC00636G

(202) H. Xu, J. S. Dickschat, Hedycaryol – Central Intermediates in Sesquiterpene Biosynthesis, Part II, Chem. Eur. J. 2022, 28, e202200405.
DOI: 10.1002/chem.202200405

(201) L. Liang, J. S. Dickschat, Enzymatic Synthesis of Variediene Analogs, Chem. Eur. J. 2022, 28, e202200095.
DOI: 10.1002/chem.202200095

(200a) Z. Quan, A. Hou, B. Goldfuss, J. S. Dickschat, Mechanismus der Bifunktionalen Multiprodukt-Sesterterpensynthase AcAS aus Aspergillus calidoustus, Angew. Chem. 2022, 134, e202117273.
DOI: 10.1002/ange.202117273
(200b) Z. Quan, A. Hou, B. Goldfuss, J. S. Dickschat, Mechanism of the Bifunctional Multiple Product Sesterterpene Synthase AcAS from Aspergillus calidoustus, Angew. Chem. Int. Ed. 2022, 61, e202117273.
DOI: 10.1002/anie.202117273

(199) Y.-H. Wang, H. Xu, J. Zou, X.-B. Chen, Y.-Q. Zhuang, W.-L. Liu, E. Celik, G.-D. Chen, D. Hu, H. Gao, R. Wu, P.-H. Sun, J. S. Dickschat, Catalytic Role of Carbonyl Oxygens and Water in Selinadiene Synthase, Nat. Catal. 2022, 5, 128-135.
DOI: 10.1038/s41929-022-00735-0

(198) H. Xu, N. Lackus, T. G. Köllner, J. S. Dickschat, Isotopic Labeling Experiments Solve the Hedycaryol Problem, Org. Lett. 2022, 24, 587-591.
DOI: 10.1021/acs.orglett.1c04021

(197) H. Li, J. S. Dickschat, Isotopic Labelling Experiments and Enzymatic Preparation of Iso-Casbenes with Casbene Synthase from Ricinus communis, Org. Chem. Front. 2022, 9, 795-801.
DOI: 10.1039/D1QO01707A

(196) H. Xu, B. Goldfuss, G. Schnakenburg, J. S. Dickschat, The Enzyme Mechanism of Patchoulol Synthase, Beilstein J. Org. Chem. 2022, 18, 13-24.
DOI: 10.3762/bjoc.18.2

(195) H. Xu, J. S. Dickschat, Mechanistic Investigations on Microbial Type I Terpene Synthases through Site-directed Mutagenesis, Synthesis 2022, 54, 1551-1565.
DOI: 10.1055/a-1675-8208

(194) M. Avalos, P. Garbeva, L. Vader, G. P. van Wezel, J. S. Dickschat, D. Ulanova, Biosynthesis, Evolution and Ecology of Microbial Terpenoids, Nat. Prod. Rep. 2022, 39, 249-272.
DOI: 10.1039/D1NP00047K

(193) A. Hou, J. S. Dickschat, The EI-MS fragmentation mechanisms of the bacterial diterpenes polytrichastrene A and wanju-2,5-diene, Eur. J. Org. Chem. 2021, 6417-6423.
DOI: 10.1002/ejoc.202101151

(192) H. Xu, C. Schotte, R. J. Cox, J. S. Dickschat, Stereochemical Characterisation of the Non-Canonical α-Humulene Synthase from Acremonium strictum, Org. Biomol. Chem. 2021, 19, 8482-8486.
DOI: 10.1039/D1OB01769A

(191) A. Hou, J. S. Dickschat, Targeting Active Site Residues and Structural Anchoring Positions in Terpene Synthases, Beilstein J. Org. Chem. 2021, 17, 2441-2449.
DOI: 10.3762/bjoc.17.161

(190) A. Hou, J. S. Dickschat, Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues, Chem. Eur. J. 2021, 27, 15644-15649.
DOI: 10.1002/chem.202103049

(189a) A. Hou, B. Goldfuss, J. S. Dickschat, Funktionaler Schalter und Ethylgruppenbildung der Bakteriellen Polytrichastrensynthase aus Chryseobacterium polytrichastri, Angew. Chem. 2021, 133, 20949-20953.
DOI: 10.1002/ange.202109465
(189b) A. Hou, B. Goldfuss, J. S. Dickschat, Functional Switch and Ethyl Group Formation in the Bacterial Polytrichastrene Synthase from Chryseobacterium polytrichastri, Angew. Chem. Int. Ed. 2021, 60, 20781-20785.
DOI: 10.1002/anie.202109465

(188a) M. Luo, H. Xu, Y. Dong, K. Shen, J. Lu, Z. Yin, M. Qi, G. Sun, L. Tang, J. Xiang, Z. Deng, J. S. Dickschat, Y. Sun, Der Mechanismus von dehydatisierenden Bimodulen in der trans-Acyltransferase-Polyketidbiosynthese: Eine Modellstudie am hepatoprotektiven Hangtaimycin, Angew. Chem. 2021, 133, 19288-19292.
DOI: 10.1002/ange.202106250
(188b) M. Luo, H. Xu, Y. Dong, K. Shen, J. Lu, Z. Yin, M. Qi, G. Sun, L. Tang, J. Xiang, Z. Deng, J. S. Dickschat, Y. Sun, The Mechanism of Dehydrating Bimodules in trans-Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective Hangtaimycin, Angew. Chem. Int. Ed. 2021, 60, 19139-19143.
DOI: 10.1002/anie.202106250

(187) Y. Duan, M. Toplak, A. Hou, N. L. Brock, J. S. Dickschat, R. Teufel, A flavoprotein dioxygenase steers bacterial tropone biosynthesis via coenzyme A-ester oxygenolysis and ring epoxidation, J. Am. Chem. Soc. 2021, 143, 10413-10421.
DOI: 10.1021/jacs.1c04996

(186) H. Xu, B. Goldfuss, J. S. Dickschat, 1,2- or 1,3-Hydride Shifts – What controls Guaiane Biosynthesis, Chem. Eur. J. 2021, 27, 9758-9762.
DOI: 10.1002/chem.202101371

(185) F. Schalk, C. Gostincar, N. Kreuzenbeck, B. Schantz-Conlon, E. Sommerwerk, P. Rabe, I. Burkhardt, T. Krüger, O. Kniemeyer, A. Brakhage, N. Gunde-Cimerman, W. De Beer, J. S. Dickschat, M. Poulsen, C. Beemelmanns, The termite fungal cultivar Termitomyces combines diverse enzymes and oxidative reactions for plant biomass conversion, mBio 2021, 12, e03551-20.
DOI: 10.1128/mBio.03551-20

(184) L. Lauterbach, A. Hou, J. S. Dickschat, Rerouting and Improving Dauc-8-en-11-ol Synthase from Streptomyces venezuelae to a High Yielding Biocatalyst, Chem. Eur. J. 2021, 27, 7923-7929.
DOI: 10.1002/chem.202100962

(183) A. K. Chhalodia, J. S. Dickschat, Breakdown of 3-(Allylsulfonio)propanoates in Bacteria from the Roseobacter Group Yields Garlic Oil Constituents, Beilstein J. Org. Chem. 2021, 17, 569-580.
DOI: 10.3762/bjoc.17.51

(182) G. Li, Y.-W. Guo, J. S. Dickschat, The mass spectrometric fragmentation mechanisms of catenulane and isocatenulane diterpenes, Org. Biomol. Chem. 2021, 19, 2224-2232.
DOI: 10.1039/D1OB00160D

(181) A. K. Chhalodia, J. Rinkel, D. Konvalinkova, J. Petersen, J. S. Dickschat, Identification of volatiles from six marine Celeribacter strains, Beilstein J. Org. Chem. 2021, 17, 420-430.
DOI: 10.3762/bjoc.17.38

(180) N. D. Lackus, J. Morawetz, H. Xu, J. Gershenzon, J. S. Dickschat, T. G. Köllner, The sesquiterpene synthase PtTPS5 produces (1S,5S,7R,10R)-guaia-4(15)-en-11-ol and (1S,7R,10R)-guaia-4-en-11-ol in oomycete-infected poplar roots, Molecules 2021, 26, 555.
DOI: 10.3390/molecules26030555

(179) H. Xu, J. Rinkel, J. S. Dickschat, Isoishwarane Synthase from Streptomyces lincolnensis, Org. Chem. Front. 2021, 8, 1177-1184.
DOI: 10.1039/D0QO01583K

(178) Z. Yin, J. S. Dickschat, Cis double bond formation in polyketide biosynthesis, Nat. Prod. Rep. 2021, 38, 1445-1468.
DOI: 10.1039/D0NP00091D

(177) G. Li, L.-L. Sun, J. S. Dickschat, Y.-W. Guo, Klyflaccilins B-T, Polyoxgenated Eunicellins from the Soft Coral Klyxum flaccidum, Eur. J. Org. Chem. 2021, 1402-1406.
DOI: 10.1002/ejoc.202001647

(176) H. Xu, J. Rinkel, X. Chen, T. G. Köllner, F. Chen, J. S. Dickschat, Mechanistic Divergence between (4S,7R)-Germacra-(1(10)E,5E)-dien-11-ol Synthases from Dictyostelium purpureum and Streptomyces coelicolor, Org. Biolmol. Chem. 2021, 19, 370-374.
DOI: 10.1039/D0OB02361B

(175a) G. Li, Y.-W. Guo, J. S. Dickschat, Diterpen-Biosynthese in Catenulispora acidiphila: Über den Mechanismus der Catenul-14-en-6-ol-Synthase, Angew. Chem. 2021, 133, 1510-1514.
DOI: 10.1002/ange.202014180
(175b) G. Li, Y.-W. Guo, J. S. Dickschat, Diterpene Biosynthesis in Catenulispora acidiphila: On the Mechanism of Catenul-14-en-6-ol Synthase, Angew. Chem. Int. Ed. 2021, 60, 1488-1492.
DOI: 10.1002/anie.202014180

(174) H. Xu, J. S. Dickschat, Revision of the Cyclisation Mechanism for the Diterpene Spiroviolene and Investigations on its Mass Spectrometric Fragmentation, ChemBioChem 2021, 22, 850-854.
DOI: 10.1002/cbic.202000682

(173) A. Hou, J. S. Dickschat, On the mass spectrometric fragmentations of the bacterial sesterterpenes sestermobaraenes A – C, Beilstein J. Org. Chem. 2020, 16, 2807-2819.
DOI: 10.3762/bjoc.16.231

(172) Z. Quan, J. S. Dickschat, The biosynthetic gene cluster for asperterpenols A and B and the cyclization mechanism of asperterpenol A synthase, Org. Lett. 2020, 22, 7552-7555.
DOI: 10.1021/acs.orglett.0c02748

(171) L. Lauterbach, J. S. Dickschat, Volatiles from the Psychrotolerant Bacterium Chryseobacterium polytrichastri, ChemBioChem 2020, 21, 3608-3617.
DOI: 10.1002/cbic.202000503

(170a) A. Hou, J. S. Dickschat, Biosynthesegencluster für Sestermobaraene – Entdeckung einer Geranylfarnesyldiphosphatsynthase und einer Multiprodukt-Sesterterpensynthase aus Streptomyces mobaraensis, Angew. Chem. 2020, 132, 20135-20140.
DOI: 10.1002/ange.202010084
(170b) A. Hou, J. S. Dickschat, The Biosynthetic Gene Cluster for Sestermobaraenes – Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase from Streptomyces mobaraensis, Angew. Chem. Int. Ed. 2020, 59, 19961-19965.
DOI: 10.1002/anie.202010084

(169) Z. Quan, J. S. Dickschat, On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments, Org. Biomol. Chem. 2020, 18, 6072-6076.
DOI: 10.1039/D0OB01470B

(168) X. Cao, Y. Shi, S. Wu, X. Wu, K. Wang, H. Sun, S. He, J. S. Dickschat, B. Wu, Polycyclic meroterpenoids, talaromyolides E - K for antiviral activity against pseudorabies virus from the endophytic fungus Talaromyces purpureogenus, Tetrahedron 2020, 76, 131349.
DOI: 10.1016/j.tet.2020.131349

(167) H. Xu, J. S. Dickschat, Germacrene A - A Central Intermediate in Sesquiterpene Biosynthesis, Chem. Eur. J. 2020, 26, 17318-17341.
DOI: 10.1002/chem.202002163

(166) G. Li, J. S. Dickschat, Y.-W. Guo, Diving into the World of Marine 2,11-Cyclized Cembranoids: A Summary of New Compounds and Their Biological Activities, Nat. Prod. Rep. 2020, 37, 1367-1383.
DOI: 10.1039/D0NP00016G

(165a) L. Lauterbach, B. Goldfuss, J. S. Dickschat, Zwei Diterpensynthasen aus Chryseobacterium: Chryseodien-Synthase und Wanjudien-Synthase, Angew. Chem. 2020, 132, 12041-12045.
DOI: 10.1002/ange.202004691
(165b) L. Lauterbach, B. Goldfuss, J. S. Dickschat, Two Diterpene Synthases from Chryseobacterium: Chryseodiene Synthase and Wanjudiene Synthase, Angew. Chem. Int. Ed. 2020, 59, 11943-11947.
DOI: 10.1002/anie.202004691

(164) L. Lauterbach, J. S. Dickschat, Sesquiterpene Synthases for Bungoene, Pentalenene and epi-Isozizaene from Streptomyces bungoensis, Org. Biomol. Chem. 2020, 18, 4547-4550.
DOI: 10.1039/D0OB00606H

(163) F. L. Lin, L. Lauterbach, J. Zhou, Y. H. Wang, J. M. Lv, G. D. Chen, D. Hu, H. Gao, X. S. Yao, J. S. Dickschat, Mechanistic Characterization of the Fusicoccane-Type Diterpene Synthase for Myrothec-15(17)-en-7-ol, ACS Catal. 2020, 10, 4306-4312.
DOI: 10.1021/acscatal.0c00377

(162) V. Harms, A. Kirschning, J. S. Dickschat, Nature-driven approaches to non-natural terpene analogs, Nat. Prod. Rep. 2020, 37, 1080-1097.
DOI: 10.1039/C9NP00055K

(161) A. A. Richter, S. Kobus, L. Czeck, A. Höppner, J. Zarzycki, T. J. Erb, L. Lauterbach, J. S. Dickschat, E. Bremer, S. H. J. Smits, The architecture of the diaminobutyrate acetyltransferase active site provides mechanistic insight into the biosynthesis of the chemical chaperone ectoine, J. Biol. Chem. 2020, 295, 2822-2838.
DOI: 10.1074/jbc.RA119.011277

(160) A. Hou, L. Lauterbach, J. S. Dickschat, Enzymatic Synthesis of Methylated Terpene Analogs Using the Plasticity of Bacterial Terpene Synthases, Chem. Eur. J. 2020, 26, 2178-2182.
DOI: 10.1002/chem.201905827

(159) J. Rinkel, J. S. Dickschat, Mechanistic Studies on Trichoacorenol Synthase from Amycolatopsis benzoatilytica, ChemBioChem 2020, 21, 807-810.
DOI: 10.1002/cbic.201900584

(158) J. Rinkel, S. T. Steiner, G. Bian, R. Chen, T. Liu, J. S. Dickschat, A Family of Related Fungal and Bacterial Di- and Sesterterpenes: Studies on Fusaterpenol and Variediene, ChemBioChem 2020, 21, 486-491.
DOI: 10.1002/cbic.201900462

(157) J. S. Dickschat, Biosynthesis of Diterpenoid Natural Products, in: Comprehensive Natural Products III: Chemistry and Biology, Vol. 1, (Eds.: T. P. Begley, H. W. Liu, Vol. Ed.: I. Abe), Elsevier,  2020, 506-552.
DOI: 10.1016/B978-0-12-409547-2.14624-4

(156) I. Burkhardt, Z. Ye, S. Janevska, B. Tudzynski, J. S. Dickschat, Biochemical and Mechanistic Characterization of the fungal reverse N-1-Dimethylallyltryptophan Synthase DMATS1Ff, ACS Chem. Biol. 2019, 14, 2922-2931.
DOI: 10.1021/acschembio.9b00828

(155) J. Rinkel, J. S. Dickschat, Characterization of Micromonocyclol Synthase from the Marine Actinomycete Micromonospora marina, Org. Lett. 2019, 21, 9442-9445.
DOI: 10.1021/acs.orglett.9b03654

(154) J. Rinkel, T. G. Köllner, F. Chen, J. S. Dickschat, Characterisation of Three Terpene Synthases for β-Barbatene, β-Araneosene and Nephthenol from Social Amoebae, ChemComm 2019, 55, 13255-13258.
DOI: 10.1039/C9CC07681F

(153a) K. Murai, L. Lauterbach, K. Teramoto, Z. Quan, L. Barra, T. Yamamoto, K. Nonaka, K. Shiomi, M. Nishiyama, T. Kuzuyama, J. S. Dickschat, Eine ungewöhnliche Gerüstumlagerung in der Biosynthese des Sesquiterpens Trichobrasilenol aus Trichoderma, Angew. Chem. 2019, 131, 15188-15192.
DOI: 10.1002/ange.201907964
(153b) K. Murai, L. Lauterbach, K. Teramoto, Z. Quan, L. Barra, T. Yamamoto, K. Nonaka, K. Shiomi, M. Nishiyama, T. Kuzuyama, J. S. Dickschat, An Unusual Skeletal Rearrangement in the Biosynthesis of the Sesquiterpene Trichobrasilenol from Trichoderma, Angew. Chem. Int. Ed. 2019, 58, 15046-15050.
DOI: 10.1002/anie.201907964

(152) X. Cao, Y. Shi, X. Wu, K. Wang, S. Huang, H. Sun, J. S. Dickschat, B. Wu, Talaromyolides A-D and Talaromytin: Polycyclic Meroterpenoids from the Fungus Talaromyces sp. CX11, Org. Lett. 2019, 21, 6539-6542.
DOI: 10.1021/acs.orglett.9b02466

(151) Q. Jia, X. Chen, T. G. Köllner, J. Rinkel, J. Fu, J. Labbé, W. Xiong, J. S. Dickschat, J. Gershenzon, F. Chen, Terpene Synthase Genes Originated from Bacteria through Horizontal Gene Transfer Contribute to Terpene Diversity in Fungi, Sci. Rep. 2019, 9, 9223.
DOI: 10.1038/s41598-019-45532-1

(150a) J. S. Dickschat, Bakterielle Diterpenbiosynthese, Angew. Chem. 2019, 131, 16110-16123.
DOI: 10.1002/ange.201905312
(150b) J. S. Dickschat, Bacterial Diterpene Biosynthesis, Angew. Chem. Int. Ed. 2019, 58, 15964-15976.
DOI: 10.1002/anie.201905312

(149) L. Martin-Sanchez, K. S. Singh, M. Avalos, G. P. van Wezel, J. S. Dickschat, P. Garbeva, Phylogenomic analyses and distribution of terpene synthases among Streptomyces, Beilstein J. Org. Chem. 2019, 15, 1181-1193.
DOI: 10.3762/bjoc.15.115

(148) X. Chen, K. Luck, P. Rabe, C. Q. D. Dinh, G. Shaulsky, D. R. Nelson, J. Gershenzon, J. S. Dickschat, T. G. Köllner, F. Chen, A Terpene Synthase-Cytochrome P450 Cluster in Dictyostelium discoideum Produces a Novel Trisnorsesquiterpene, eLife 2019, 8, e44352.
DOI: 10.7554/eLife.44352

(147a) J. Rinkel, S. T. Steiner, J. S. Dickschat, Diterpen-Biosynthese in Actinomyceten: Studien an Cattleyensynthase und Phomopsensynthase, Angew. Chem. 2019, 131, 9328-9332.
DOI: 10.1002/ange.201902950
(147b) J. Rinkel, S. T. Steiner, J. S. Dickschat, Diterpene Biosynthesis in Actinomycetes: Studies on Cattleyene Synthase and Phomopsene Synthase, Angew. Chem. Int. Ed. 2019, 58, 9230-9233.
DOI: 10.1002/anie.201902950

(146) J. Rinkel, J. S. Dickschat, Mechanistic investigations on multiproduct β-himachalene synthase from Cryptosporangium arvum, Beilstein J. Org. Chem. 2019, 15, 1008-1019.
DOI: 10.3762/bjoc.15.99

(145) L. Lauterbach, T. Wang, M. Stadler, J. S. Dickschat, Volatiles from the ascomycete Daldinia cf. childiae (Hypoxylaceae), originating from China, Med. Chem. Comm. 2019, 10, 726-734.
DOI: 10.1039/C9MD00083F

(144) J. Rinkel, J. S. Dickschat, Stereochemical investigations on the biosynthesis of achiral (Z)-γ-bisabolene in Cryptosporangium arvum, Beilstein J. Org. Chem. 2019, 15, 789-794.
DOI: 10.3762/bjoc.15.75

(143) J. Rinkel, J. S. Dickschat, Addressing the Chemistry of Germacrene A by Isotope Labeling Experiments, Org. Lett. 2019, 21, 2426-2429.
DOI: 10.1021/acs.orglett.9b00725

(142) L. Czech, A. Höppner, S. Kobus, A. Seubert, R. Riclea, J. S. Dickschat, J. Heider, S. H. J. Smits, E. Bremer, Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis, Sci. Rep. 2019, 9, 364.
DOI: 10.1038/s41598-018-36247-w

(141) I. Burkhardt, N. Kreuzenbeck, C. Beemelmanns, J. S. Dickschat, Mechanistic Characterization of Three Sesquiterpene Synthases from the Termite-Associated Fungus Termitomyces, Org. Biomol. Chem. 2019, 17, 3348-3355.
DOI: 10.1039/C8OB02744G

(140) A. Beyraghdar Kashkooli, A. van der Krol, P. Rabe, J. S. Dickschat, H. Bouwmeester, Substrate promiscuity of enzymes from the sesquiterpene biosynthesis pathways from Artemisia annua and Tanacetum parthenium allow for novel combinatorial sesquiterpene production, Metab. Eng. 2019, 54, 12-23.
DOI: 10.1016/j.ymben.2019.01.007

(139) J. Rinkel, P. Rabe, J. S. Dickschat, The EI-MS fragmentation mechanisms of bacterial sesquiterpenes and diterpenes, Eur. J. Org. Chem. 2019, 351-359.
DOI: 10.1002/ejoc.201800217

(138a) J. Rinkel, L. Lauterbach, J. S. Dickschat, Eine verzweigte Diterpen-Kaskade: Der Mechanismus der Spinodien-Synthase aus Saccharopolyspora spinosa, Angew. Chem. 2019, 131, 461-465.
DOI: 10.1002/ange.201812216
(138b) J. Rinkel, L. Lauterbach, J. S. Dickschat, A Branched Diterpene Cascade: The Mechanism of Spinodiene Synthase from Saccharopolyspora spinosa, Angew. Chem. Int. Ed. 2019, 58, 452-455.
DOI: 10.1002/anie.201812216

(137) J. Rinkel, A. Babczyk, T. Wang, M. Stadler, J. S. Dickschat, Volatiles from the hypoxylaceous fungi Hypoxylon griseobrunneum and Hypoxylon macrocarpum, Beilstein J. Org. Chem. 2018, 14, 2974-2990.
DOI: 10.3762/bjoc.14.277

(136a) G. Bian, J. Rinkel, Z. Wang, L. Lauterbach, A. Hou, Y. Yuan, Z. Deng, T. Liu, J. S. Dickschat, Eine chimäre pilzliche Diterpensynthase der Klade II-D aus Colletotrichum gloeosporioides macht Dolasta-1(15),8-dien, Angew. Chem. 2018, 130, 16113-16117.
DOI: 10.1002/ange.201809954
(136b) G. Bian, J. Rinkel, Z. Wang, L. Lauterbach, A. Hou, Y. Yuan, Z. Deng, T. Liu, J. S. Dickschat, A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Making Dolasta-1(15),8-diene, Angew. Chem. Int. Ed. 2018, 57, 15887-15890.
DOI: 10.1002/anie.201809954

(135) X. Chen, T. G. Köllner, G. Shaulsky, Q. Jia, J. S. Dickschat, J. Gershenzon, F. Chen, Diversity and Functional Evolution of Terpene Synthases in Dictyostelid Social Amoebae, Sci. Rep. 2018, 8, 14361.
DOI: 10.1038/s41598-018-32639-0

(134a) C. Oberhauser, V. Harms, K. Seidel, B. Schröder, K. Ekramzadeh, S. Beutel, S. Winkler, L. Lauterbach, J. S. Dickschat, A. Kirschning, Nutzung des biosynthetischen Potentials von Sesquiterpencyclasen zur Herstellung unnatürlicher Terpene, Angew. Chem. 2018, 130, 11976-11980.
DOI: 10.1002/ange.201805526
(134b) C. Oberhauser, V. Harms, K. Seidel, B. Schröder, K. Ekramzadeh, S. Beutel, S. Winkler, L. Lauterbach, J. S. Dickschat, A. Kirschning, Exploiting the synthetic potential of sesquiterpene cyclases for generating unnatural terpenoids, Angew. Chem. Int. Ed. 2018, 57, 11802-11806.
DOI: 10.1002/anie.201805526

(133) Q. Zhang, J. Rinkel, B. Goldfuß, J. S. Dickschat, K. Tiefenbacher, Sesquiterpene Cyclisations Catalysed inside the Resorcinarene Capsule and Application in the Short Synthesis of Isolongifolene and Isolongifolenone, Nat. Catal. 2018, 1, 609-615.
DOI: 10.1038/s41929-018-0115-4

(132a) L. Lauterbach, J. Rinkel, J. S. Dickschat, Zwei bakterielle Diterpensynthasen aus Allokutzneria albata für Bonnadien und für Phomopsen und Allokutzneren, Angew. Chem. 2018, 130, 8412-8415.
DOI: 10.1002/ange.201803800
(132b) L. Lauterbach, J. Rinkel, J. S. Dickschat, Two Bacterial Diterpene Synthases from Allokutzneria albata for Bonnadiene and for Phomopsene and Allokutznerene, Angew. Chem. Int. Ed. 2018, 57, 8280-8283.
DOI: 10.1002/anie.201803800

(131) L. Ziesche, J. Rinkel, J. S. Dickschat, S. Schulz, Acyl group specificity of AHL-synthases involved in Quorum-sensing in Roseobacter group bacteria, Beilstein J. Org. Chem. 2018, 14, 1309-1316.
DOI: 10.3762/bjoc.14.112

(130) K. Hoogendoorn, L. Barra, C. Waalwijk, J. S. Dickschat, T. van der Lee, M. H. Medema, Evolution and diversity of biosynthetic gene clusters in Fusarium, Front. Microbiol. 2018, 9, 1158.
DOI: 10.3389/fmicb.2018.01158

(129) J. Rinkel, M. Litzenburger, R. Bernhardt, J. S. Dickschat, An Isotopic Labelling Strategy to Study Cytochrome P450 Oxidations of Terpenes, ChemBioChem 2018, 19, 1498-1501.
DOI: 10.1002/cbic.201800215

(128) R. Schmidt, M. B. Durling, V. de Jager, R. C. Menezes, E. Nordkvist, A. Svatos, M. Dubey, L. Lauterbach, J. S. Dickschat, M. Karlsson, P. Garbeva, Deciphering the genome and secondary metabolome of the plant pathogen Fusarium culmorum, FEMS Microbiol. Ecol. 2018, 94, fiy078.
DOI: 10.1093/femsec/fiy078

(127) I. Burkhardt, J. S. Dickschat, Synthesis and Absolute Configuration of Natural 2-Pyrones, Eur. J. Org. Chem. 2018, 3144-3157.
DOI: 10.1002/ejoc.201800621

(126) J. S. Dickschat, E. Celik, N. L. Brock, Volatiles from three genome sequenced fungi from the genus Aspergillus, Beilstein J. Org. Chem. 2018, 14, 900-910.
DOI: 10.3762/bjoc.14.77

(125) M. J. Kschowak, H. Wortmann, J. S. Dickschat, J. Schrader, M. Buchhaupt, Heterologous expression of 2-methylisoborneol / 2-methylenebornane biosynthesis genes in Escherichia coli yields novel C11-terpenes, PLoS ONE 2018, 13, e0196082.
DOI: 10.1371/journal.pone.0196082

(124) J. S. Dickschat, T. Wang, M. Stadler, Volatiles from the xylarialean fungus Hypoxylon invadens, Beilstein J. Org. Chem. 2018, 14, 734-746.
DOI: 10.3762/bjoc.14.62

(123) I. Burkhardt, J. S. Dickschat, The Absolute Configuration of Isochamigrene: New Insights into the Cyclisation Mechanism of Trichodiene Synthase, ChemComm 2018, 54, 3540-3542.
DOI: 10.1039/C8CC01744A

(122) M. Kohlstedt, S. Starck, N. Barton, J. Stolzenberger, M. Selzer, K. Mehlmann, R. Schneider, D. Pleissner, J. Rinkel, J. S. Dickschat, J. Venus, J. van Duuren, C. Wittmann, From lignin to nylon: Enhanced biological funneling of aromatics using Pseudomonas putida with metabolically engineered catechol tolerance and conversion efficiency, Metab. Eng. 2018, 47, 279-293.
DOI: 10.1016/j.ymben.2018.03.003

(121a) J. Rinkel, L. Lauterbach, P. Rabe, J. S. Dickschat, Zwei Diterpensynthasen für Spiroalbaten und Cembren A aus Allokutzneria albata, Angew. Chem. 2018, 130, 3292-3296.
DOI: 10.1002/ange.201800385
(121b) J. Rinkel, L. Lauterbach, P. Rabe, J. S. Dickschat, Two Diterpene Synthases for Spiroalbatene and Cembrene A from Allokutzneria albata, Angew. Chem. Int. Ed. 2018, 57, 3238-3241.
DOI: 10.1002/anie.201800385

(120) T. Wang, K. I. Mohr, M. Stadler, J. S. Dickschat, Volatiles from the tropical ascomycete Daldinia clavata (Hypoxylaceae, Xylariales), Beilstein J. Org. Chem. 2018, 14, 135-147.
DOI: 10.3762/bjoc.14.9

(119a) J. Rinkel, L. Lauterbach, J. S. Dickschat, Spata-13,17-dien-Synthase, ein Enzym mit Sesqui-, Di- und Sesterterpen-Synthase-Aktivität aus Streptomyces xinghaiensis, Angew. Chem. 2017, 129, 16603-16607.
DOI: 10.1002/ange.201711142
(119b) J. Rinkel, L. Lauterbach, J. S. Dickschat, Spata-13,17-diene Synthase, an Enzyme with Sesqui-, Di- and Sesterterpene Synthase Activity from Streptomyces xinghaiensis, Angew. Chem. Int. Ed. 2017, 56, 16385-16389.
DOI: 10.1002/anie.201711142

(118) L. Barra, J. S. Dickschat, Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma, ChemBioChem 2017, 18, 2358-2365.
DOI: 10.1002/cbic.201700462

(117) J. S. Dickschat, J. Rinkel, T. Klapschinski, J. Petersen, Characterisation of the L-cystine β-lyase PatB from Phaeobacter inhibens, an enzyme involved in the biosynthesis of the marine antibiotic tropodithietic acid, ChemBioChem 2017, 18, 2260-2267.
DOI: 10.1002/cbic.201700358

(116) A. Schulz, L. Hermann, S. Freibert, T. Bönig, T. Hoffmann, R. Riclea, J. S. Dickschat, J. Heider, E. Bremer, Transcriptional regulation of ectoine catabolism in response to multiple metabolic and environmental cues, Environ. Microbiol. 2017, 19, 4599-4619.
DOI: 10.1111/1462-2920.13924

(115) L. Barra, P. Barac, G. M. König, M. Crüsemann, J. S. Dickschat, Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea, Org. Biomol. Chem. 2017, 15, 7411-7421.
DOI: 10.1039/C7OB01837A

(114) J. S. Dickschat, J. Rinkel, P. Rabe, A. Beyraghdar Kashkooli, H. J. Bouwmeester, 18-Hydroxydolabella-3,7-diene synthase – a diterpene synthase from Chitinophaga pinensis, Beilstein J. Org. Chem. 2017, 13, 1770-1780.
DOI: 10.3762/bjoc.13.171

(113) L. Barra, J. S. Dickschat, Sceptrin - Enantioselective Synthesis of a Tetrasubstituted all-trans Cyclobutane Key Intermediate, Eur. J. Org. Chem. 2017, 4566-4571.
DOI: 10.1002/ejoc.201700882

(112) T. Mitsuhashi, J. Rinkel, M. Okada, I. Abe, J. S. Dickschat, Mechanistic Characterization of two Chimeric Sesterterpene Synthases from Penicillium, Chem. Eur. J. 2017, 23, 10053-10057.
DOI: 10.1002/chem.201702766

(111) J. Rinkel, P. Rabe, X. Chen, T. G. Köllner, F. Chen, J. S. Dickschat, Mechanisms of the Diterpene Cyclases β-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus, Chem. Eur. J. 2017, 23, 10501-10505.
DOI: 10.1002/chem.201702704

(110) E.-M. Niehaus, J. Schumacher, I. Burkhardt, P. Rabe, M. Münsterkötter, U. Güldener, J. S. Dickschat, B. Tudzynski, The GATA-type transcription factor Csm1 regulates conidiation and secondary metabolism in Fusarium fujikuroi, Front. Microbiol. 2017, 8, 1175.
DOI: 10.3389/fmicb.2017.01175

(109) I. Burkhardt, L. Lauterbach, N. L. Brock, J. S. Dickschat, Chemical Differentiation of Three DMSP Lyases from the Marine Roseobacter group, Org. Biomol. Chem. 2017, 15, 4432-4439.
DOI: 10.1039/C7OB00913E

(108) J. S. Dickschat, Modern Aspects of Isotopic Labellings in Terpene Biosynthesis, Eur. J. Org. Chem. 2017, 4872-4882.
DOI: 10.1002/ejoc.201700482

(107) K. Blin, T. Wolf, M. G. Chevrette, X. Lu, C. J. Schwalen, S. A. Kautsar, H. G. Suarez Duran, E. L.C. de los Santos, H. U. Kim, M. Nave, J. S. Dickschat, D. A. Mitchell, E. Shelest, R. Breitling, E. Takano, S. Y. Lee, T. Weber, M. H. Medema, antiSMASH 4.0 — Improvements in Chemistry Prediction and Gene Cluster Boundary Identification, Nucl. Acids Res. 2017, 45, W36-W41.
DOI: 10.1093/nar/gkx319

(106) E. Celik, M. Maczka, N. Bergen, T. Brinkhoff, S. Schulz, J. S. Dickschat, Metabolism of 2,3-dihydroxypropane-1-sulfonate by marine bacteria, Org. Biomol. Chem. 2017, 15, 2919-2922.
DOI: 10.1039/C7OB00357A

(105) P. Rabe, M. Samborskyy, P. F. Leadlay, J. S. Dickschat, Isoafricanol Synthase from Streptomyces malaysiensis, Org. Biomol. Chem. 2017, 15, 2353-2358.
DOI: 10.1039/C7OB00234C

(104) J. S. Dickschat, Fungal Volatiles - A Survey from Edible Mushrooms to Moulds, Nat. Prod. Rep. 2017, 34, 310-328.
DOI: 10.1039/C7NP00003K

(103a) P. Rabe, J. Rinkel, E. Dolja, T. Schmitz, B. Nubbemeyer, T. H. Luu, J. S. Dickschat, Mechanistische Studien an zwei bakteriellen Diterpencyclasen: Spiroviolen-Synthase und Tsukubadien-Synthase, Angew. Chem. 2017, 129, 2820-2823.
DOI: 10.1002/ange.201612439
(103b) P. Rabe, J. Rinkel, E. Dolja, T. Schmitz, B. Nubbemeyer, T. H. Luu, J. S. Dickschat, Mechanistic investigantions on two bacterial diterpene cyclases: Spiroviolene Synthase and Tsukubadiene Synthase, Angew. Chem. Int. Ed. 2017, 56, 2776-2779.
DOI: 10.1002/anie.201612439

(102) O. Tyc, C. Song, J. S. Dickschat, M. Vos, P. Garbeva, The ecological role of volatile and soluble secondary metabolites produced by soil bacteria, Trends Microbiol. 2017, 25, 280-292.
DOI: 10.1016/j.tim.2016.12.002

(101) S. Janevska, B. Arndt, E.-M. Niehaus, I. Burkhardt, S. M. Rösler, N. L. Brock, H.-U. Humpf, J. S. Dickschat, B. Tudzynski, Gibepyrone biosynthesis in the rice pathogen Fusarium fujikuroi is facilitated by a small polyketide synthase gene cluster, J. Biol. Chem. 2016, 291, 27403-27420.
DOI: 10.1074/jbc.M116.753053

(100) M. Münsterkötter, E.-M. Niehaus, R. H. Proctor, D. W. Brown, A. Sharon, Y. Idan, L. Oren-Young, C. M. Sieber, O. Novak, A. Pencik, D. Tarkowska, K. Hromadova, S. Freeman, M. Maymon, M. Elazar, S. A. Youssef, E. M. El-Shabrawy, A. A. Shalaby, P. Houterman, N. L. Brock, I. Burkhardt, E. A. Tsavkelova, J. S. Dickschat, P. Galuszka, U. Güldener, B. Tudzynski, Comparative 'omics' of the Fusarium fujikuroi species complex highlights differences in genetic potential and metabolite synthesis, Genome Biol. Evol. 2016, 8, 3574-3599.
DOI: 10.1093/gbe/evw259

(99) R. Nett, J. S. Dickschat, R. Peters, Labeling studies clarify the committed step in bacterial gibberellin biosynthesis, Org. Lett. 2016, 18, 5974-5977.
DOI: 10.1021/acs.orglett.6b02569

(98) J. Rinkel, P. Rabe, L. zur Horst, J. S. Dickschat, A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus, Beilstein J. Org. Chem. 2016, 12, 2317-2324.
DOI: 10.3762/bjoc.12.225

(97a) P. Rabe, J. Rinkel, B. Nubbemeyer, T. G. Köllner, F. Chen, J. S. Dickschat, Terpencyclasen aus sozialen Amöben, Angew. Chem. 2016, 128, 15646-15649.
DOI: 10.1002/ange.201608971
(97b) P. Rabe, J. Rinkel, B. Nubbemeyer, T. G. Köllner, F. Chen, J. S. Dickschat, Terpene Cyclases from Social Amoebae, Angew. Chem. Int. Ed. 2016, 55, 15420-15423.
DOI: 10.1002/anie.201608971

(96a) M. M. Mohseni, T. Höver, L. Barra, M. Kaiser, P. C. Dorrestein, J. S. Dickschat, T. F. Schäberle, Entdeckung einer Mosaik-ähnlichen Biosynthesemaschinerie mit einem decarboxylierenden Entladungsmechanismus durch die Kombination von Genom-Mining und bildgebenden Verfahren, Angew. Chem. 2016, 128, 13809-13813.
DOI: 10.1002/ange.201606655
(96b) M. M. Mohseni, T. Höver, L. Barra, M. Kaiser, P. C. Dorrestein, J. S. Dickschat, T. F. Schäberle, Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging, Angew. Chem. Int. Ed. 2016, 55, 13611-13614.
DOI: 10.1002/anie.201606655

(95a) J. Rinkel, P. Rabe, P. Garbeva, J. S. Dickschat, Über 1,3-Hydridverschiebungen in Sesquiterpen-Zyklisierungen, Angew. Chem. 2016, 128, 13791-13794.
DOI: 10.1002/ange.201608042
(95b) J. Rinkel, P. Rabe, P. Garbeva, J. S. Dickschat, Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclisations, Angew. Chem. Int. Ed. 2016, 55, 13593-13596.
DOI: 10.1002/anie.201608042

(94) X. Chen, T. G. Köllner, Q. Jia, A. Norris, B. Santhanam, P. Rabe, J. S. Dickschat, G. Shaulsky, J. Gershenzon, F. Chen, Terpene Synthase Genes in Eukaryotes Beyond Plants and Fungi: Domain-wide Analysis of Distribution and Functional Investigation in the Social Amoeba Dictyostelium discoideum, Proc. Natl. Acad. Sci. USA 2016, 113, 12132-12137.
DOI: 10.1073/pnas.161037911

(93) P. Rabe, T. Schmitz, J. S. Dickschat, Mechanistic Investigations on Six Bacterial Terpene Cyclases, Beilstein J. Org. Chem. 2016, 12, 1839-1850.
DOI: 10.3762/bjoc.12.173

(92) P. Rabe, J. S. Dickschat, The EIMS fragmentation mechanisms of the sesquiterpenes corvol ethers A and B, epi-cubebol and isodauc-8-en-11-ol, Beilstein J. Org. Chem. 2016, 12, 1380-1394.
DOI: 10.3762/bjoc.12.132

(91a) T. A. Klapschinski, P. Rabe, J. S. Dickschat, Pristinol, ein Sesquiterpen-Alkohol mit ungewöhnlichem Skelett aus Streptomyces pristinaespiralis, Angew. Chem. 2016, 128, 10296-10299.
DOI: 10.1002/ange.201605425
(91b) T. A. Klapschinski, P. Rabe, J. S. Dickschat, Pristinol, a Sesquiterpene Alcohol with Unprecedented Skeleton from Streptomyces pristinaespiralis, Angew. Chem. Int. Ed. 2016, 55, 10141-10144.
DOI: 10.1002/anie.201605425

(90) L. Studt, S. M. Rösler, I. Burkhardt, B. Arndt, M. Freitag, H.-U. Humpf, J. S. Dickschat, B. Tudzynski, Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi, Environ. Microbiol. 2016, 18, 4037-4054.
DOI: 10.1111/1462-2920.13427

(89a) I. Burkhardt, T. Siemon, M. Henrot, L. Studt, S. Rösler, B. Tudzynski, M. Christmann, J. S. Dickschat, Mechanistische Charakterisierung von zwei Sesquiterpencyclasen aus dem phytopathogenen Pilz Fusarium fujikuroi, Angew. Chem. 2016, 128, 8890-8893.
DOI: 10.1002/ange.201603782
(89b) I. Burkhardt, T. Siemon, M. Henrot, L. Studt, S. Rösler, B. Tudzynski, M. Christmann, J. S. Dickschat, Mechanistic Characterisation of two Sesquiterpene Cyclases from the Plant Pathogenic Fungus Fusarium fujikuroi, Angew. Chem. Int. Ed. 2016, 55, 8748-8751.
DOI: 10.1002/anie.201603782

(88) P. Rabe, T. A. Klapschinski, J. S. Dickschat, Position-specific mass shift analysis: a systematic method to investigate the EI-MS fragmentation mechanism of epi-isozizaene, ChemBioChem 2016, 17, 1333-1337.
DOI: 10.1002/cbic.201600237

(87) N. Widderich, S. Kobus, A. Höppner, R. Riclea, A. Seubert, J. S. Dickschat, J. Heider, S. H. J. Smits, E. Bremer, Biochemistry and Crystal Structure of Ectoin Synthase: a Metal-Containing Member of the Cupin Superfamily, PLoS ONE 2016, 11, e0151285.
DOI: 10.1371/journal.pone.0151285

(86) N. Widderich, L. Czech, F. J. Elling, M. Könneke, N. Stöveken, M. Pittelkow, R. Riclea, J. S. Dickschat, J. Heider, E. Bremer, Strangers in the archaeal world: Osmostress-responsive biosynthesis of ectoine and hydroxyectoine by the marine thaumarchaeon Nitrosopumilus maritimus, Environ. Microbiol. 2016, 18, 1227-1248.
DOI: 10.1111/1462-2920.13156

(85) L. Studt, S. Janevska, E.-M. Niehaus, I. Burkhardt, B. Arndt, H.-U. Humpf, J. S. Dickschat, B. Tudzynski, Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi, Environ. Microbiol. 2016, 18, 936-956.
DOI: 10.1111/1462-2920.13150

(84) P. Rabe, A. Janusko, B. Goldfuss, J. S. Dickschat, Experimental and theoretical studies on corvol ether biosynthesis, ChemBioChem 2016, 17, 146-149.
DOI: 10.1002/cbic.201500543

(83) J. S. Dickschat, Bacterial Terpene Cyclases, Nat. Prod. Rep. 2016, 33, 87-110.
DOI: 10.1039/C5NP00102A

(82) P. Rabe, J. Rinkel, T. A. Klapschinski, L. Barra, J. S. Dickschat, A method for investigating the stereochemical course of terpene cyclisations, Org. Biomol. Chem. 2016, 14, 158-164.
DOI: 10.1039/C5OB01998B

(81) J. Rinkel, J. S. Dickschat, Recent highlights in biosynthesis research using stable isotopes, Beilstein J. Org. Chem. 2015, 11, 2493-2508.
DOI: 10.3762/bjoc.11.271

(80a) P. Rabe, L. Barra, J. Rinkel, R. Riclea, C. A. Citron, T. A. Klapschinski, A. Janusko, J. S. Dickschat, Konformationsanalyse, thermische Umlagerung und EI-MS-Fragmentierungsmechanismus von (1(10)E,4E,6S,7R)-Germacradien-6-ol durch ¹³C-Markierungsexperimente, Angew. Chem. 2015, 127, 13649-13653.
DOI: 10.1002/ange.201507615
(80b) P. Rabe, L. Barra, J. Rinkel, R. Riclea, C. A. Citron, T. A. Klapschinski, A. Janusko, J. S. Dickschat, Conformational Analysis, Thermal Rearrangement and EI-MS-Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by ¹³C-Labeling Experiments, Angew. Chem. Int. Ed. 2015, 54, 13448-13451.
DOI: 10.1002/anie.201507615

(79a) R. Riclea, J. S. Dickschat, Identifizierung von Intermediaten der PR Toxin-Biosynthese durch Penicillium roqueforti, Angew. Chem. 2015, 127, 12335-12338.
DOI: 10.1002/ange.201506128
(79b) R. Riclea, J. S. Dickschat, Identification of Intermediates in PR Toxin Biosynthesis by Penicillium roqueforti, Angew. Chem. Int. Ed. 2015, 54, 12167-12170.
DOI: 10.1002/anie.201506128

(78) B.-E. Priegnitz, U. Brandt, K. A. K. Pahirulzaman, J. S. Dickschat, A. Fleißner, The AngFus3 MAP kinase controls hyphal differentiation and secondary metabolism in Aspergillus niger, Eukaryot. Cell 2015, 14, 602-615.
DOI: 10.1128/EC.00018-15

(77a) L. Barra, K. Ibrom, J. S. Dickschat, Strukturrevision und Biosynthese von Hypodoratoxid per ¹³C,¹³C-COSY-NMR, Angew. Chem. 2015, 127, 6737-6740.
DOI: 10.1002/ange.201501765
(77b) L. Barra, K. Ibrom, J. S. Dickschat, Structural Revision and Biosynthesis of Hypodoratoxide by ¹³C,¹³C-COSY-NMR, Angew. Chem. Int. Ed. 2015, 54, 6637-6640.
DOI: 10.1002/anie.201501765

(76a) P. Rabe, K. A. K. Pahirulzaman, J. S. Dickschat, Strukturen und Biosynthese der Corvol-Ether - Sesquiterpene aus dem Actinomyceten Kitasatospora setae, Angew. Chem. 2015, 127, 6139-6143.
DOI: 10.1002/ange.201501119
(76b) P. Rabe, K. A. K. Pahirulzaman, J. S. Dickschat, Structures and Biosynthesis of Corvol Ethers - Sesquiterpenes from the Actinomycete Kitasatospora setae, Angew. Chem. Int. Ed. 2015, 54, 6041-6045.
DOI: 10.1002/anie.201501119

(75) C. A. Citron, L. Barra, J. Wink, J. S. Dickschat, Volatiles from Nineteen Recently Genome Sequenced Actinomycetes, Org. Biomol. Chem. 2015, 13, 2673-2683.
DOI: 10.1039/C4OB02609H

(74) J. S. Dickschat, P. Rabe, C. A. Citron, The Chemical Biology of Dimethylsulfoniopropionate, Org. Biomol. Chem. 2015, 13, 1954-1968.
DOI: 10.1039/C4OB02407A

(73) S. Broy, C. Chen, T. Hoffmann, N. L. Brock, G. Nau-Wagner, M. Jebbar, S. H. J. Smits, J. S. Dickschat, E. Bremer, Abiotic Stress Protection by Ecologically Abundant DMSP and its Natural and Synthetic Derivatives: Insights from Bacillus subtilis, Environ. Microbiol. 2015, 17, 2362-2378.
DOI: 10.1111/1462-2920.12698

(72) C. A. Citron, P. Rabe, L. Barra, C. Nakano, T. Hoshino, J. S. Dickschat, Synthesis of Isotopically Labelled Oligoprenyl Diphosphates and Their Application in Mechanistic Investigations of Terpene Cyclases, Eur. J. Org. Chem. 2014, 7684-7691.
DOI: 10.1002/ejoc.201403002

(71) L. Barra, B. Schulz, J. S. Dickschat, Pogostol Biosynthesis by the Endophytic Fungus Geniculosporium, ChemBioChem 2014, 15, 2379-2383.
DOI: 10.1002/cbic.201402298

(70) P. Rabe, T. A. Klapschinski, N. L. Brock, C. A. Citron, P. D'Alvise, L. Gram, J. S. Dickschat, Synthesis and Bioactivity of Analogs of the Marine Antibiotic Tropodithietic Acid, Beilstein J. Org. Chem. 2014, 10, 1796-1801.
DOI: 10.3762/bjoc.10.188

(69) N. L. Brock, M. Menke, T. A. Klapschinski, J. S. Dickschat, Marine Bacteria from the Roseobacter Clade Produce Sulfur Volatiles via Amino Acid and Dimethylsulfoniopropionate Catabolism, Org. Biomol. Chem. 2014, 12, 4318-4323.
DOI: 10.1039/C4OB00719K

(68a) P. Baer, P. Rabe, K. Fischer, C. A. Citron, T. A. Klapschinski, M. Groll, J. S. Dickschat, Substratinduzierte Konformationsänderungen in Klasse-I-Terpencyclasen, Angew. Chem. 2014, 126, 7783-7787.
DOI: 10.1002/ange.201403648
(68b) P. Baer, P. Rabe, K. Fischer, C. A. Citron, T. A. Klapschinski, M. Groll, J. S. Dickschat, Induced Fit Mechanism in Class I Terpene Cyclases, Angew. Chem. Int. Ed. 2014, 53, 7652-7656.
DOI: 10.1002/anie.201403648

(67) U. Groenhagen, M. Maczka, J. S. Dickschat, S. Schulz, Streptopyridines, volatile pyridine alkaloids produced by Streptomyces sp. FORM5, Beilstein J. Org. Chem. 2014, 10, 1421-1432.
DOI: 10.3762/bjoc.10.146

(66) N. L. Brock, A. Nikolay, J. S. Dickschat, Biosynthesis of the Antibiotic Tropodithietic Acid by the Marine Bacterium Phaeobacter inhibens, ChemComm 2014, 50, 5487-5489.
DOI: 10.1039/C4CC01924E

(65) C. A. Citron, N. L. Brock, B. Tudzynski, J. S. Dickschat, Labelling Studies on the Biosynthesis of Terpenes in Fusarium fujikuroi, ChemComm 2014, 50, 5224-5226.
DOI: 10.1039/C3CC45982A

(64) R. Riclea, C. A. Citron, J. Rinkel, J. S. Dickschat, Identification of Isoafricanol and its Terpene Cyclase in Streptomyces violaceusniger by CLSA-NMR, ChemComm 2014, 50, 4228-4230.
DOI: 10.1039/C4CC00177J

(63a) C. A. Citron, C. Junker, B. Schulz, J. S. Dickschat, Ein flüchtiges Lacton aus Hymenoscyphus pseudoalbidus, Pathogen des Europäischen Eschensterbens, inhibiert die Keimung seines Wirtes, Angew. Chem. 2014, 126, 4435-4438.
DOI: 10.1002/ange.201402290
(63b) C. A. Citron, C. Junker, B. Schulz, J. S. Dickschat, A Volatile Lactone of Hymenoscyphus pseudoalbidus, Pathogen of European Ash Dieback, Inhibits Host Germination, Angew. Chem. Int. Ed. 2014, 53, 4346-4349.
DOI: 10.1002/anie.201402290

(62) S. Halecker, F. Surup, E. Kuhnert, K. I. Mohr, N. L. Brock, J. S. Dickschat, C. Junker, B. Schulz, M. Stadler, Hymenosetin, a 3-decalinoyltetramic acid antibiotic from cultures of the ash dieback pathogen, Hymenoscyphus pseudoalbidus, Phytochemistry 2014, 100, 86-91.
DOI: 10.1016/j.phytochem.2014.01.018

(61) J. S. Dickschat, K. A. K. Pahirulzaman, P. Rabe, T. A. Klapschinski, An Improved Technique for the Rapid Chemical Characterisation of Bacterial Terpene Cyclases, ChemBioChem 2014, 15, 810-814.
DOI: 10.1002/cbic.201300763

(60) J. S. Dickschat, Capturing Volatile Natural Products by Mass Spectrometry, Nat. Prod. Rep. 2014, 31, 838-861.
DOI: 10.1039/C3NP70080A

(59) R. Bunet, R. Riclea, L. Laureti, L. Hotel, C. Paris, J.-M. Girardet, D. Spiteller, J. S. Dickschat, P. Leblond, B. Aigle, A major role for a single Sfp-type PPTase in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877, PLoS ONE 2014, 9, e87607.
DOI: 10.1371/journal.pone.0087607

(58) C. A. Citron, J. S. Dickschat, Microbial Terpenes: A Perspective on Their Chemistry and Biosynthesis, Synlett 2014, 25, 766-782.
DOI: 10.1055/s-0033-1340624

(57) P. Baer, P. Rabe, C. A. Citron, C. C. de Oliveira Mann, N. Kaufmann, M. Groll, J. S. Dickschat, Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism, ChemBioChem 2014, 15, 213-216.
DOI: 10.1002/cbic.201300708

(56) B. Aigle, S. Lautru, D. Spiteller, J. S. Dickschat, G. L. Challis, P. Leblond, J.-L. Pernodet, Genome mining of Streptomyces ambofaciens, J. Ind. Microbiol. Biotechnol. 2014, 41, 251-263.
DOI: 10.1007/s10295-013-1379-y

(55) C. A. Citron, J. S. Dickschat, [²H₂₆]-1-epi-Cubenol, a completely deuterated natural product from Streptomyces griseus, Beilstein J. Org. Chem. 2013, 9, 2841-2845.
DOI: 10.3762/bjoc.9.319

(54) T. Wang, P. Rabe, C. A. Citron, J. S. Dickschat, Halogenated Volatiles from the Fungus Geniculosporium and the Actinomycete Streptomyces chartreusis, Beilstein J. Org. Chem. 2013, 9, 2767-2777.
DOI: 10.3762/bjoc.9.311

(53) C. A. Citron, J. S. Dickschat, The Stereochemical Course of Tricho-Acorenol Biosynthesis, Org. Biomol. Chem. 2013, 11, 7447-7450.
DOI: 10.1039/C3OB41755G

(52) P. Rabe, C. A. Citron, J. S. Dickschat, Volatile Terpenes from Actinomycetes - A Biosynthetic Study Correlating Chemical Analyses to Genome Data, ChemBioChem 2013, 14, 2345-2354.
DOI: 10.1002/cbic.201300329

(51) N. L. Brock, J. S. Dickschat, Biosynthesis of Terpenoids, in: Handbook of Natural Products, K. G. Ramawat, J.-M. Mérillon (Eds.), Springer, 2013, 2693-2732.
DOI: 10.1007/978-3-642-22144-6_121

(50) W. Arendt, M. Groenewold, S. Hebecker, J. S. Dickschat, J. Moser, Identification and characterization of a periplasmic Aminoacyl-Phosphatidylglycerol Hydrolase responsible for Pseudomonas aeruginosa lipid homeostasis, J. Biol. Chem. 2013, 288, 24717-24730.
DOI: 10.1074/jbc.M113.482935

(49) N. L. Brock, J. S. Dickschat, PR Toxin Biosynthesis in Penicillium roqueforti, ChemBioChem 2013, 14, 1189-1193.
DOI: 10.1002/cbic.201300254

(48) N. L. Brock, C. A. Citron, C. Zell, M. Berger, I. Wagner-Döbler, J. Petersen, T. Brinkhoff, M. Simon, J. S. Dickschat, Isotopically Labeled Sulfur Compounds and Synthetic Selenium and Tellurium Analogs to Study Sulfur Metabolism in Marine Bacteria, Beilstein J. Org. Chem. 2013, 9, 942-950.
DOI: 10.3762/bjoc.9.108

(47) P. Kielkowski, N. L. Brock, J. S. Dickschat, M. Hocek, Nucleobase Protection Strategy for Gene Cloning and Expression, ChemBioChem 2013, 14, 801-804.
DOI: 10.1002/cbic.201300127

(46) S. M. Wickel, C. A. Citron, J. S. Dickschat, Novel 2H-Pyran-2-ones from Trichoderma viride and Trichoderma asperellum, Eur. J. Org. Chem. 2013, 2906-2913.
DOI: 10.1002/ejoc.201300049

(45) N. L. Brock, K. Huss, B. Tudzynski, J. S. Dickschat, Genetic Dissection of Sesquiterpene Biosynthesis by Fusarium fujikuroi, ChemBioChem 2013, 14, 311-315.
DOI: 10.1002/cbic.201200695

(44a) N. L. Brock, S. R. Ravella, S. Schulz, J. S. Dickschat, Eine Nahaufnahme der 2-Methylisoborneol-Biosynthese, Angew. Chem. 2013, 125, 2154-2158.
DOI: 10.1002/ange.201209173
(44b) N. L. Brock, S. R. Ravella, S. Schulz, J. S. Dickschat, A Detailed View of 2-Methylisoborneol Biosynthesis, Angew. Chem. Int. Ed. 2013, 52, 2100-2104.
DOI: 10.1002/anie.201209173

(43a) P. Rabe, J. S. Dickschat, Schnelle Chemische Charakterisierung Bakterieller Terpensynthasen, Angew. Chem. 2013, 125, 1855-1857.
DOI: 10.1002/ange.201209103
(43b) P. Rabe, J. S. Dickschat, Rapid Chemical Characterisation of Bacterial Terpene Synthases, Angew. Chem. Int. Ed. 2013, 52, 1810-1812.
DOI: 10.1002/anie.201209103

(42) S. Hahnke, N. L. Brock, C. Zell, M. Simon, J. S. Dickschat, T. Brinkhoff, Physiological diversity of Roseobacter clade bacteria co-occurring during a phytoplankton bloom in the North Sea, Syst. Appl. Microbiol. 2013, 36, 39-48.
DOI: 10.1016/j.syapm.2012.09.004

(41) C. A. Citron, P. Rabe, J. S. Dickschat, The Scent of Bacteria: Headspace Analysis for the Discovery of Natural Products, J. Nat. Prod. 2012, 75, 1765-1776.
DOI: 10.1021/np300468h

(40) C. A. Citron, S. M. Wickel, B. Schulz, S. Draeger, J. S. Dickschat, A Diels-Alder / Retro-Diels-Alder Approach for the Enantioselective Synthesis of Microbial Butenolides, Eur. J. Org. Chem. 2012, 6636-6646.
DOI: 10.1002/ejoc.201200991

(39) R. Riclea, J. Gleitzmann, H. Bruns, C. Junker, B. Schulz, J. S. Dickschat, Algicidal Lactones from the Marine Roseobacter Clade Bacterium Ruegeria pomeroyi, Beilstein J. Org. Chem. 2012, 8, 941-950.
DOI: 10.3762/bjoc.8.106

(38) R. Riclea, B. Aigle, P. Leblond, I. Schoenian, D. Spiteller, J. S. Dickschat, Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway, ChemBioChem 2012, 13, 1635-1644.
DOI: 10.1002/cbic.201200260

(37) P. Wiemann, S. Albermann, E.-M. Niehaus, L. Studt, K. W. von Bargen, N. L. Brock, H.-U. Humpf, J. S. Dickschat, B. Tudzynski, The Sfp-Type 4'-Phosphopantetheinyl Transferase Ppt1 of Fusarium fujikuroi Controls Development, Secondary Metabolism and Pathogenicity, PLoS ONE 2012, 7, e37519-e37533.
DOI: 10.1371/journal.pone.0037519

(36) M. Berger, N. L. Brock, H. Liesegang, M. Docks, I. Preuth, M. Simon, J. S. Dickschat, T. Brinkhoff, Genetic Analysis of the Upper Phenylacetate Catabolic Pathway in the Production of Tropodithietic Acid by Phaeobacter gallaeciensis, Appl. Environ. Microbiol. 2012, 78, 3539-3551.
DOI: 10.1128/AEM.07657-11

(35a) C. A. Citron, N. L. Brock, P. Rabe, J. S. Dickschat, Der stereochemische Verlauf und Mechanismus der IspH-Reaktion, Angew. Chem. 2012, 124, 4129-4133.
DOI: 10.1002/ange.201201110
(35b) C. A. Citron, N. L. Brock, P. Rabe, J. S. Dickschat, The Stereochemical Course and Mechanism of the IspH Reaction, Angew. Chem. Int. Ed. 2012, 51, 4053-4057.
DOI: 10.1002/anie.201201110

(34) I. Schoenian, C. Paetz, J. S. Dickschat, B. Aigle, P. Leblond, D. Spiteller, An unprecedented 1,2-shift in the biosynthesis of the 3-amino-salicylate moiety of antimycins, ChemBioChem 2012, 13, 769-773.
DOI: 10.1002/cbic.201200033

(33) A. L. Rodriguez, Y. Göcke, C. J. Bolten, N. L. Brock, J. S. Dickschat, C. Wittmann, Microbial production of the drugs violacein and deoxyviolacein - analytical development and strain comparison, Biotechnol. Lett. 2012, 34, 717-720.
DOI: 10.1007/s10529-011-0827-x

(32) C. A. Citron, J. Gleitzmann, G. Laurenzano, R. Pukall, J. S. Dickschat, Terpenoids are Widespread in Actinomycetes: A Correlation of Secondary Metabolism and Genome Data, ChemBioChem 2012, 13, 202-214.
DOI: 10.1002/cbic.201100641

(31) J. S. Dickschat, H. Bruns, R. Riclea, Novel Fatty Acid Methyl Esters from the Actinomycete Micromonospora aurantiaca, Beilstein J. Org. Chem., 2011, 7, 1697-1712.
DOI: 10.3762/bjoc.7.200

(30) N. L. Brock, B. Tudzynski, J. S. Dickschat, Biosynthesis of Sesqui- and Diterpenes by the Gibberellin Producer Fusarium fujikuroi, ChemBioChem 2011, 12, 2667-2676.
DOI: 10.1002/cbic.201100516

(29) J. S. Dickschat, Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis, Nat. Prod. Rep. 2011, 28, 1917-1936.
DOI: 10.1039/C1NP00063B

(28) J. S. Dickschat, O. Vergnolle, H. Hong, S. Garner, S. R. Bidgood, H. C. Dooley, Z. Deng, P. F. Leadlay, Y. Sun, An Additional Dehydratase-like Activity is Required for Lankacidin Antibiotic Biosynthesis, ChemBioChem 2011, 12, 2408-2412.
DOI: 10.1002/cbic.201100474

(27) R. Riclea, J. S. Dickschat, The Absolute Configuration of the Pyrrolosesquiterpenoid Glaciapyrrol A, Chem. Eur. J. 2011, 17, 11930-11934.
DOI: 10.1002/chem.201101139

(26) J. S. Dickschat, N. L. Brock, C. A. Citron, B. Tudzynski, Biosynthesis of Sesquiterpenes by the Fungus Fusarium verticillioides, ChemBioChem 2011, 12, 2088-2095.
DOI: 10.1002/cbic.201100268

(25) N. L. Brock, J. S. Dickschat, Enantioselective Synthesis of the Unnatural Enantiomers of the Fungal Sesquiterpenoids Acorenone and Trichoacorenol, Eur. J. Org. Chem. 2011, 5167-5175.
DOI: 10.1002/ejoc.201100688

(24) C. A. Citron, R. Riclea, N. L. Brock, J. S. Dickschat, Biosynthesis of Acorane Sesquiterpenes by Trichoderma, RSC Advances 2011, 1, 290-297.
DOI: 10.1039/C1RA00212K

(23) J. S. Dickschat, C. A. Citron, N. L. Brock, R. Riclea, H. Kuhz, Synthesis of Deuterated Mevalonolactone Isotopomers, Eur. J. Org. Chem. 2011, 3339-3346.
DOI: 10.1002/ejoc.201100188

(22) S. Schulz, J. S. Dickschat, B. Kunze, I. Wagner-Döbler, R. Diestel, F. Sasse, Biological Activity of Volatiles from Marine and Terrestrial Bacteria, Mar. Drugs 2010, 8, 2976-2987.
DOI: 10.3390/md8122976

(21) C. J. Bolten, H. Schröder, J. S. Dickschat, C. Wittmann, Towards Methionine Overproduction in Corynebacterium glutamicum – Methanethiol and Dimethyldisulfide as Reduced Sulfur Sources, J. Microbiol. Biotechnol. 2010, 20, 1196-1203.
DOI: 10.4014/jmb.1002.02018

(20) T. Nawrath, J. S. Dickschat, B. Kunze, S. Schulz, The Biosynthesis of Branched Dialkylpyrazines in Myxobacteria, Chem. Biodivers. 2010, 7, 2129-2144.
DOI: 10.1002/cbdv.201000158

(19) J. S. Dickschat, S. Wickel, C. J. Bolten, T. Nawrath, S. Schulz, C. Wittmann, Pyrazine Biosynthesis in Corynebacterium glutamicum, Eur. J. Org. Chem. 2010, 2687-2695.
DOI: 10.1002/ejoc.201000155

(18) J. S. Dickschat, Quorum sensing and bacterial biofilms, Nat. Prod. Rep. 2010, 27, 343-369.
DOI: 10.1039/B804469B

(17) J. S. Dickschat, C. Zell, N. L. Brock, Pathways and substrate specificity of DMSP catabolism in marine bacteria of the Roseobacter clade, ChemBioChem 2010, 11, 417-425.
DOI: 10.1002/cbic.200900668

(16) V. Thiel, T. Brinkhoff, J. S. Dickschat, S. Wickel, J. Grunenberg, I. Wagner-Döbler, M. Simon, S. Schulz, Identification and biosynthesis of tropone derivatives and sulfur volatiles produced by bacteria of the marine Roseobacter clade, Org. Biomol. Chem. 2010, 8, 234-246.
DOI: 10.1039/B909133E

(15) P. Meiser, K. J. Weissman, H. B. Bode, D. Krug, J. S. Dickschat, A. Sandmann, R. Müller, DKxanthene Biosynthesis - Understanding the Basis for Diversity-Oriented Synthesis in Myxobacterial Secondary Metabolism, Chem. Biol. 2008, 15, 771-781.
DOI: 10.1016/j.chembiol.2008.06.005

(14) T. Nawrath, J. S. Dickschat, R. Müller, J. Jiang, D. E. Cane, S. Schulz, Identification of (8S,9S,10S)-8,10-dimethyl-1-octalin, a key intermediate in the biosynthesis of geosmin in bacteria, J. Am. Chem. Soc. 2008, 130, 430-431.
DOI: 10.1021/ja077790y

(13a) J. S. Dickschat, T. Nawrath, V. Thiel, B. Kunze, R. Müller, S. Schulz, Biosynthese des Duftstoffes 2-Methylisoborneol durch das Myxobakterium Nannocystis exedens, Angew. Chem. 2007, 119, 8436-8439.
DOI: 10.1002/ange.200702496
(13b) J. S. Dickschat, T. Nawrath, V. Thiel, B. Kunze, R. Müller, S. Schulz, Biosynthesis of the Off-flavor 2-Methylisoborneol by the Myxobacterium Nannocystis exedens, Angew. Chem. Int. Ed. 2007, 46, 8287-8290.
DOI: 10.1002/anie.200702496

(12) S. Schulz, J. S. Dickschat, Bacterial Volatiles: The Smell of Small Organisms, Nat. Prod. Rep. 2007, 24, 814-842.
DOI: 10.1039/B507392H

(11a) A. Sandmann, J. S. Dickschat, H. Jenke-Kodama, B. Kunze, E. Dittmann, R. Müller, Aurachin-Biosynthese im Gram-negativen Bakterium Stigmatella aurantiaca: Beteiligung einer Typ-II-Polyketidsynthase, Angew. Chem. 2007, 119, 2768-2772.
DOI: 10.1002/ange.200603513
(11b) A. Sandmann, J. S. Dickschat, H. Jenke-Kodama, B. Kunze, E. Dittmann, R. Müller, A Type II Polyketide Synthase from the Gram-Negative Bacterium Stigmatella aurantiaca is Involved in Aurachin Alkaloid Biosynthesis, Angew. Chem. Int. Ed. 2007, 46, 2712-2716.
DOI: 10.1002/anie.200603513

(10) M. W. Ring, G. Schwär, V. Thiel, J. S. Dickschat, R. M. Kroppenstedt, S. Schulz, H. B. Bode, Novel Iso-Branched Ether Lipids as Specific Markers of Developmental Sporulation in the Myxobacterium Myxococcus xanthus, J. Biol. Chem. 2006, 281, 36691-36700.
DOI: 10.1074/jbc.M607616200

(9) J. S. Dickschat, H. B. Bode, S. C. Wenzel, R. Müller, S. Schulz, Biosynthesis and Identification of Volatiles Released by the Myxobacterium Stigmatella aurantiaca, ChemBioChem 2005, 6, 2023-2033.
DOI: 10.1002/cbic.200500174

(8) J. S. Dickschat, H. Reichenbach, I. Wagner-Döbler, S. Schulz, Novel Pyrazines from the Myxobacterium Chondromyces crocatus and Marine Bacteria, Eur. J. Org. Chem. 2005, 4141-4153.
DOI: 10.1002/ejoc.200500280

(7) J. S. Dickschat, H. B. Bode, R. M. Kroppenstedt, R. Müller, S. Schulz, Biosynthesis of Iso-Fatty Acids in Myxobacteria, Org. Biomol. Chem. 2005, 3, 2824-2831.
DOI: 10.1039/B504889C

(6) J. S. Dickschat, T. Martens, T. Brinkhoff, M. Simon, S. Schulz, Volatiles Released by a Marine Streptomycete form the North Sea, Chem. Biodivers. 2005, 2, 837-865.
DOI: 10.1002/cbdv.200590062

(5) J. S. Dickschat, H. B. Bode, T. Mahmud, R. Müller, S. Schulz, A Novel Type of Geosmin Biosynthesis in Myxobacteria, J. Org. Chem. 2005, 70, 5174-5182.
DOI: 10.1021/jo050449g

(4) J. S. Dickschat, I. Wagner-Döbler, S. Schulz, The Chafer Pheromone Buibuilactone and Ant Pyrazines are also Produced by Marine Bacteria, J. Chem. Ecol. 2005, 31, 925-947.
DOI: 10.1007/s10886-005-3553-9

(3) J. S. Dickschat, E. Helmke, S. Schulz, Volatile Organic Compounds from Arctic Bacteria of the Family Flavobacteriaceae. A Retrobiosynthetic Approach in Chemotaxonomic Investigations, Chem. Biodivers. 2005, 2, 318-353.
DOI: 10.1002/cbdv.200590014

(2) H. B. Bode, J. S. Dickschat, R. M. Kroppenstedt, S. Schulz, R. Müller, Biosynthesis of Iso-Fatty Acids in Myxobacteria: Iso-Even Fatty Acids are Derived by α-Oxidation from Iso-Odd Fatty Acids, J. Am. Chem. Soc. 2005, 127, 532-533.
DOI: 10.1021/ja043570y

(1) J. S. Dickschat, S. C. Wenzel, H. B. Bode, R. Müller, S. Schulz, Biosynthesis of Volatiles by the Myxobacterium Myxococcus xanthus, ChemBioChem 2004, 5, 778-787.
DOI: 10.1002/cbic.200300813