GDCh-Kolloquium Professor Dr. David Powers

Making, Seeing, and Using Subvalent Nitrogen Species
Direct C H amination chemistry via electrophilic subvalent nitrogen intermediates could radically simplify access to nitrogen containing small molecules by providing the chemical tools to selectively convert ubiquitous C H bonds to valuable C N bonds At present, challenges in chemoselectivity sustainability, and synthetic versatility prevent realization of the synthetic potential of C H amination.This talk will describe recent efforts from the Powers Laboratory that advance 1 new strategies to structurally characterize transient intermediates in C H functionalization reactions, 2 novel metal free approaches to the sustainable generation of strong oxidants needed in C H functionalization reactions, and 3 bifunctional reagent platforms that enable rapid elaboration of the primary products of C H amination Future directions and challenges will be discussed.